All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive inhibitor of ...
Cerebral microvessels were lysed in the Laemmli buffer (0.125 mM TrisHCl, pH 6.8, containing 10% glycerol, 2.5% SDS, 0.006% bromphenol blue, and 0.1 M dithiothreitol) for 10 min at 100°C (10). Each ...
The discovery of cyclooxygenase (COX) isoforms, COX-1 and COX-2, in the early 1990s helped explain how non-steroidal anti-inflammatory drugs (NSAIDs) work and led to specific agents with fewer ...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of pain and inflammation. Emerging pharmacokinetic and pharmacodynamic evidence in NSAID pharmacology provides important ...
A plausible mechanism has emerged which suggests that cyclooxygenase-2 (COX-2) inhibitors might expose otherwise predisposed individuals to thrombotic or systemic hypertensive complications. There is ...
N. V. Chandrasekharan, Hu Dai, K. Lamar Turepu Roos, Nathan K. Evanson, Joshua Tomsik, Terry S. Elton, Daniel L. Simmons Proceedings of the National Academy of ...
THE LAUNCH OF THE CYCLOOXYGENASE-2 (COX-2) selective NSAIDs was based on 2 hypotheses: (1) the major adverse effects limiting the usefulness of nonselective NSAIDs are gastrointestinal in nature and ...
"Very lame and imperfect theories are sufficient to suggest useful experiments which serve to correct those theories and give birth to others more perfect. These, then occasion farther experiments ...
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