Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In a new ...

Eukaryotic chromosomes are huge DNA polymers organized in space and time. Chromatin looping compacts these polymers, helps genome organization by the formation of enhancer–promoter and other ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...