A novel tumor suppressor, BATF2, can be silenced by factors in the tumor microenvironment, leading to a reduced immune ...

BATF2 is a new type of tumor suppressor that can be epigenetically silenced by high levels of glutamine in the tumor microenvironment Glutamine silences BATF2 and leads to a weakened immune response ...

The consumption of the amino acid glutamine in cancer is somewhat of a conundrum. We know adequate glutamine levels are needed for ensuring nitrogen balance, maintaining gut integrity, and ...

Among all ovarian cancers, the worst prognosis is seen in ovarian clear cell carcinomas (OCCC) which typically don’t respond to chemotherapy. Over half of the patients with OCCC harbor ...

An analysis of the metabolic profiles of hundreds of ovarian tumors has revealed a new method for tailoring treatments for ovarian cancer and for assessing whether ovarian cancer cells have the ...

Cancer cells survive therapy by dynamically rewiring their metabolism in response to nutrient availability, ...

The importance of glutamine has been made clear as a colon cancer specific metabolism. It is known that glutamine metabolism is important for pancreatic cancer, but the importance of glutamine ...

Over one million men and women are living with colorectal cancer in the United States. The National Cancer Institute estimates 4.5% of all men and women will be diagnosed with the cancer during their ...

Glucose, which is a representative human energy source, and glutamine, a kind of amino acid, are nutrients that play an important role in human life, but cancer cells also use glucose and glutamine as ...

HOUSTON -- (May 5, 2014) -- A Rice University-led analysis of the metabolic profiles of hundreds of ovarian tumors has revealed a new test to determine whether ovarian cancer cells have the potential ...