Intracellular membrane fusion requires not only SNARE proteins but also other regulatory proteins such as the Rab and Sec1/ Munc18 (SM) family proteins. Although neuronal SNARE proteins alone can ...
The two universally required components of the intracellular membrane fusion machinery, SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular and target ...
The chaperone Hsc70 (green) helps keep SNAP-25 in the proper shape so that it can help form the SNARE complex, enabling neurotransmission. AMHERST, Mass. – A team of researchers from the University of ...
SNARE proteins dock packets, or vesicles, of neurotransmitters such as glutamate on the membrane of neurons so they can be released across the synapse. Tomosyn was also suspected to be a target of an ...
Researchers describe, for the first time, the full molecular cascade that comprises acrosomal exocytosis, an essential step in fertilization, in this week's PLoS Biology. "Exocytosis has been analyzed ...
Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson’s disease protein
Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...
A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are vital in ensuring that neurons can transmit signals to one another. When ...
A team of researchers shows how proteins called 'chaperones' are vital in ensuring that neurons can transmit signals to one another. When this neurotransmission breaks down, devastating diseases such ...
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